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DNA重组技术为制备乙型肝炎疫苗提供了多种新的可能性:(1)乙型肝炎病毒(HBV)的22nm颗粒可在用克隆的HBV DNA转染的真核细胞(动物细胞或酵母)中产生;(2)通过转化的细菌合成外壳蛋白主要多肽或具有HBsAg活性的杂交多肽;(3)化学合成带有一种HBsAg决定簇的寡肽;(4)利用其
DNA recombination technology offers many new possibilities for the preparation of hepatitis B vaccines: (1) 22 nm particles of Hepatitis B virus (HBV) are detectable in eukaryotic cells (animal cells or yeast) transfected with cloned HBV DNA, (2) synthesis of coat protein major polypeptides or hybrid polypeptides with HBsAg activity by transformed bacteria; (3) chemical synthesis of oligopeptides with an HBsAg determinant; (4) use of