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透射电镜下观察10只慢性镉中毒小鼠肾脏的超微结构变化。结果表明肾小体和近曲小管上皮细胞的超微结构均受到损伤。肾小体：毛细血管内皮细胞肿胀、增厚。血管系膜增生。血管球基膜增厚或分裂成层，基膜和内皮细胞之间或基膜的分裂之间有电子致密物沉积。近曲小管上皮细胞：胞核变形、固缩。线粒体肿胀、嵴断裂、脱落。细胞游离面微绒毛肿胀、变形、排列紊乱。细胞基底面质膜内褶减少或消失。这些超微结构的改变与某些类型肾小球肾炎的病理特征相似。
TEM observation of ultrastructure of kidneys in 10 chronic cadmium poisoning mice. The results showed that the ultrastructure of renal tubular cells and proximal tubule epithelial cells were damaged. Renal body: capillary endothelial cells swelling, thickening. Mesangial proliferation. Glomerular basement membrane thickened or split into layers, the basement membrane and endothelial cells or the basement membrane between the electronic densification deposition. Near tubule epithelial cells: nuclear deformation, shrinkage. Mitochondria swelling, crest fracture, fall off. Cell free surface microvilli swollen, deformed, arranged disorder. The basal cell plasma membrane reduced or disappeared. These ultrastructural changes are similar to the pathological features of some types of glomerulonephritis.