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目的:探讨乳腺浸润性微乳头状癌的临床病理特征。方法:选取2006-2011年间我院收治的乳腺浸润性微乳头状癌患者27例,对其切片标本进行病理和免疫组化检验,观察病理改变情况,分析病理特征。结果:27例患者的病理组织均具有典型的乳腺浸润性微乳头状癌病理特征。肿瘤细胞排列成的癌团为微乳头状、小腺样,且大小不等,肿瘤细胞呈中空簇状生长,乳头中心纤维血管轴心较少。其中20例有局部淋巴结转移,送检淋巴结转移率为74.1%,转移癌的形态仍保持乳头状或腺管状结构。ER阳性率为59.3%,PR阳性率为48.1%,Her-2阳性率为59.3%,CD31阳性率为59.3%,CK7与EMA阳性率均为100%。结论:通过检测分析病理特征和免疫组化特点对乳腺浸润性微乳头状癌进行诊断,能够提高诊疗及预后效果。
Objective: To investigate the clinicopathological features of breast invasive papillary carcinoma. Methods: Twenty-seven cases of invasive breast micro-papillary carcinoma admitted in our hospital from 2006 to 2011 were selected for pathological and immunohistochemical examination of the specimens. The pathological changes were observed and the pathological features were analyzed. Results: The histopathology of 27 patients had the typical pathological features of breast invasive micro-papillary carcinoma. Tumor cells were arranged in clusters of micro-papillary, small adenoid, and the size range, the tumor cells showed a hollow tufted growth, nipple center less fibrous axis. Among them, 20 cases had local lymph node metastasis, and the rate of lymph node metastasis was 74.1%. The morphology of metastatic carcinoma still maintained papillary or glandular tubular structures. The positive rate of ER was 59.3%, the positive rate of PR was 48.1%, the positive rate of Her-2 was 59.3%, the positive rate of CD31 was 59.3%, and the positive rate of CK7 and EMA was 100%. Conclusion: The diagnosis of breast invasive micro-papillary carcinoma can improve the diagnosis and prognosis by detecting the pathological features and immunohistochemical features.