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为探讨细胞因子在病毒性脑炎发病中的作用及意义,对30例腮腺炎合并脑膜脑炎患儿脑脊液测定了IL-1、IL-6、IL-8(白细胞介素-1、6、8),TNF-α(肿瘤坏死因子),结果发现急性期腮脑患儿脑脊液中上述细胞因子均较对照组明显增高(P<0.01),说明腮腺炎合并脑膜脑炎的发病与IL-1、IL-6、IL-8、TNF-α密切相关。
To investigate the role and significance of cytokines in the pathogenesis of viral encephalitis, the levels of IL-1, IL-6, IL-8 (interleukin-1, 8) and TNF-α (tumor necrosis factor). The results showed that the levels of these cytokines in cerebrospinal fluid of patients with acute stage of cheek brain were significantly higher than those of the control group (P <0.01), indicating that the incidence of mumps combined with meningoencephalitis was positively correlated with IL- , IL-6, IL-8, TNF-α are closely related.