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目的：研制阿霉素多孔磷酸三钙陶瓷（ Ａ Ｐ Ｔ Ｃ Ｐ）缓释体并为骨肿瘤保肢治疗术后骨缺损的修复提供新方法。材料与方法：制备 Ｐ Ｔ Ｃ Ｐ陶瓷，将阿霉素载入其中制得 Ａ Ｐ Ｔ Ｃ Ｐ。实验动物分成 Ａ、 Ｂ两组， Ａ 组右股骨粗隆中植入 Ａ Ｐ Ｔ Ｃ Ｐ， Ｂ组静脉注射阿霉素。不同时期取粗隆部位的肌肉及血浆标本，用高效液相色谱法测定肌肉及血浆中阿霉素的浓度。结果：体内植入 Ａ Ｐ Ｔ Ｃ Ｐ后，阿霉素能在局部缓慢释放达１０ 周以上，局部组织药浓高，全身药浓低。既能缓释阿霉素控制肿瘤复发，又能充填并修复骨缺损。结论： Ａ Ｐ Ｔ Ｃ Ｐ缓释体，可望成为骨肿瘤保肢治疗术后骨缺损修复的一种新方法。
Objective: To develop adriamycinporous tricalcium phosphate ceramics (APTCP) sustained-release body and provide a new method for the repair of bone defects after limb salvage for bone tumors. Materials and Methods: P T C P ceramics were prepared and A-P T C P was prepared by loading doxorubicin. The experimental animals were divided into two groups, A and B. Group A was implanted with A P T C P in the right femur trochanter, and group B was intravenously injected with doxorubicin. At different times, muscle and plasma specimens from the trochanter were taken and the concentrations of doxorubicin in muscle and plasma were determined by high performance liquid chromatography. RESULTS: After implantation of A-PTCP in vivo, doxorubicin could be slowly released locally for more than 10 weeks, local tissue drug concentration was high, and systemic drug concentration was low. It can not only delay the release of doxorubicin to control tumor recurrence, but also fill and repair bone defects. Conclusion: A P T C P sustained-release body is expected to be a new method for the repair of bone defects after limb salvage treatment of bone tumors.