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GATA蛋白家族成员在谱系分化和转分化过程中发挥着重要作用。之前研究通过大规模筛选发现,细胞重编程中至关重要的干性因子OCT4能够被调控中内胚层(ME)发育和分化的因子(如GATA3,GATA6,PAX1)代替,但谱系分化特异性线索与多能性激活之间的联系以及GATA蛋白如何调整两者之间平衡,在诱导过程中,如何促进体细胞向i PS的重编程,其作用机制尚不明确。中国科学院北京基因组研究所孙英丽研究组与北京大学邓宏魁研究组携手合作,通过Ch IP-Seq,RNA-Seq等多种技术手段对GATA蛋白起
Members of the GATA family of proteins play an important role in lineage differentiation and transdifferentiation. Previous studies have found through large-scale screening that OCT4, a crucial dry factor in cell reprogramming, can be replaced by factors that regulate the development and differentiation of mesendoderm (eg, GATA3, GATA6, PAX1), but lineage-specific cues And the relationship between the activation of pluripotency and GATA protein how to adjust the balance between the two, in the process of induction, how to promote reprogramming of somatic cells to i PS, its mechanism of action is not yet clear. The Chinese Academy of Sciences Beijing Genomics Institute Sun Yingli Group and Peking University Deng Hongkui research group work together through the Ch IP-Seq, RNA-Seq and other technologies to GATA protein