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用免疫组化方法检测６０例膀胱移行细胞癌增殖细胞核抗原（ＰＣＮＡ），在肿瘤Ｇ１．Ｇ２，Ｇ３级细胞中的指数分别为：２． ４±３． ９％；９． ５±１３． ０％；５４． ８±２９． ３％。 Ｇ３级显著高于 Ｇ１与 Ｇ３级（ Ｐ＜０． ０１）。浸润性肿瘤（Ｔ２—Ｔ４）５２． １±３５．１％显著高于表浅性肿瘤（Ｔａ—Ｔ１）１８±２３．４％（Ｐ＜０．０１）。将所有肿瘤平均指数３０．４±３２．３％分为ＰＣＮＡ＜３０．４和＞ ３０． ４两组，通过生存分析表明： ＰＣＮＡ指数较高组与较低组相比有不良的预后，提示 ＰＣＮＡ指数为 ＴＣＣ侵袭性生物学行为和预后提供了量化的参数。
Immunohistochemical method was used to detect the expression of proliferating cell nuclear antigen (PCNA) in 60 cases of transitional cell carcinoma of bladder and G1 in tumor. G2, G3 grade cells in the index were: 2. 4 ± 3. 9%; 9. 5 ± 13. 0%; 54. 8 ± 29. 3%. G3 level was significantly higher than the G1 and G3 level (P <0.01). Invasive tumors (T2-T4) 52. 1 ± 35.1% was significantly higher than that of superficial tumors (Ta-T1) 18 ± 23.4% (P <0.01). All tumor mean indexes 30.4 ± 32.3% were divided into PCNA <30.4 and> 30. 4 in both groups. Survival analysis showed that the higher PCNA index group had a worse prognosis than the lower group, suggesting that the PCNA index provides a quantitative parameter for invasive biological behavior and prognosis of TCC.