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目的研究特应性体质与哮喘患儿呼出气一氧化氮(FeNO)水平的相关性。方法选取2011年2月至2011年8月于中国医科大学附属盛京医院哮喘门诊就诊的哮喘患儿191例,进行FeNO测定及皮肤点刺试验。结果 191例哮喘患儿平均FeNO值为18.0(12.0～35.0)×10-9,与正常儿童相比明显增高,差异有统计学意义(Z=-9.332,P<0.001)。特应性体质患儿FeNO值为20.0(13.0～37.0)×10-9,非特应性体质患儿FeNO值为11.0(9.5～19.0)×10-9,两组比较差异有统计学意义(Z=-3.965,P<0.001)。且FeNO值随着皮肤点刺试验中变应原阳性的数量增加而增加(P<0.05)。结论特应性体质可使哮喘患儿FeNO水平升高,应用FeNO测定来指导哮喘的诊断与治疗时必须考虑到患儿的过敏状态。
Objective To study the correlation between atopic exhaustion (NO) and nitric oxide (FeNO) in children with atopic constitution and asthma. Methods From February 2011 to August 2011, 191 children with asthma admitted to the Asthma Clinic of Shengjing Hospital affiliated to China Medical University were selected for FeNO measurement and skin prick test. Results The average FeNO of 191 asthmatic children was 18.0 (12.0 ~ 35.0) × 10-9, which was significantly higher than that of normal children (Z = -9.332, P <0.001). The FeNO value of children with atopic constitution was 20.0 (13.0-37.0) × 10-9, and the FeNO value of children with non-atopic constitution was 11.0 (9.5-19.0) × 10-9. There was significant difference between the two groups (Z = -3.965, P <0.001). FeNO values increased with the number of positive allergens in skin prick test (P <0.05). Conclusion Atopic constitution can increase the level of FeNO in children with asthma. The application of FeNO measurement to guide asthma diagnosis and treatment must take into account the children’s allergy status.