【摘 要】
：
Mycosphazine A (1),a new iron(Ⅲ) chelator of coprogen-type siderophore,and mycosphamide A (2),a new cyclic amide benzoate,together with six known aryl amides (3-8),were isolated from the fermentation broth of the deep-sea-derived fungus Mycosphaerella sp.
【机 构】
：
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine
论文部分内容阅读
Mycosphazine A (1),a new iron(Ⅲ) chelator of coprogen-type siderophore,and mycosphamide A (2),a new cyclic amide benzoate,together with six known aryl amides (3-8),were isolated from the fermentation broth of the deep-sea-derived fungus Mycosphaerella sp.SCSIO z059.Alkaline hydrolysis of 1 afforded a new epimer of dimerum acid,mycosphazine B (1a),and a new bi-fusarinine-type siderophore,mycosphazine C (1b).The planar structures of the new compounds were elucidated by extensive spectroscopic data analysis.The absolute configurations of amino acid residues in 1a and 1b were determined by acid hydrolysis.And the absolute configuration of 2 was established by quantum chemical calculations of the electronic circular dichroism (ECD) spectra.Compound 1 is the first siderophore-Fe(Ⅲ) chelator incorporating both L-omithine and D-omithine unites.Compounds 3-8 were reported as natural products for the first time,and the 1H and 13C NMR data of 6 and 8 were assigned for the first time.Compounds 1 and 1acould greatly promote the biofilm formation of bacterium Bacillus amyloliquefaciens with the rate of about 249％ and 524％ at concentration of 100 μg·mL 1,respectively.
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