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为了探讨婴儿腹泻的发病机制,1965年我院给收治的重型婴儿腹泻患儿进行全面的常规检查与生化检查,并对其中16名严重患儿检查了眼底,发现有小动脉痉挛及小静脉纡曲等微循环障碍现象。同年又用福氏痢疾杆菌内毒素注入兔子体内,造成兔子休克。鉴于重型婴儿腹泻的眼底变化与中毒性痢疾相仿,从而产生用改善微循环障碍的药物治疗该病的设想。1974年3月到1976年3月共治疗218例,全部治愈。其中弪、中度患儿共174例。第二日痊愈者125例,占71.8%,且均来输液;44例重度脱水患儿中,36例仅输液一次,24小时脱水得到纠
In order to investigate the pathogenesis of infant diarrhea, we conducted a comprehensive routine examination and biochemical examination on infants with severe infantile diarrhea admitted to our hospital in 1965. We examined the fundus of 16 severe children and found arteriole spasm and vena cava Qu and other microcirculation obstacles. In the same year with Infectious Dysentery Bacillus endotoxin injected into rabbits, resulting in rabbit shock. Given the similar fundus changes in severe infantile diarrhea similar to that of toxic dysentery, the idea of treating the disease with drugs that improve microcirculation is created. From March 1974 to March 1976 a total of 218 cases were treated, all cured. Among them, a total of 174 cases of children with moderate. The second day healed 125 cases, accounting for 71.8%, and were to transfusion; 44 cases of severe dehydration in children, only 36 infusion once dehydrated 24 hours