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Nizatidine是一种有效的H_2受体拮抗剂,在人体中有很大的生物可用性,雷尼替丁生物可用性约为50%,而口服nizatidine300mg的生物可用性约为95%.本文比较夜服安慰剂,nizatidine 150mg或300mg,甲氰咪胍800mg和雷尼替丁300mg,对24小时胃内酸度及夜间胃液分泌量和胃酸排出量的作用.10例无消化性溃疡病史的正常人参加本研究.采用随机抽样交叉单盲法,每人分5天受试.在21点时分别服用安慰剂、雷尼替丁300mg、甲氰咪胍800mg、nizatidine 150mg或300mg.饮食和环境条件都相似.插入鼻胃管至胃的最远端,每天同一时间摄入含热量2600千卡的标准混合食物.从18点开始24小时期间,每隔1小时经鼻胃管吸出5～10ml胃内容物并测
Nizatidine is a potent H 2 receptor antagonist with great bioavailability in humans, with a bioavailability of about 50% for ranitidine, compared with about 95% for oral nizatidine 300 mg.This article compared nighttime placebo , nizatidine 150mg or 300mg, cimetidine 800mg and ranitidine 300mg on gastric acidity within 24 hours and nocturnal secretion of gastric juice and gastric acid secretion.The 10 normal subjects without history of peptic ulcer participated in this study. Randomized crossover, single-blind crossover was used, and each participant was tested for 5 days, with placebo, ranitidine 300 mg, cimetidine 800 mg, and nizatidine 150 mg or 300 mg at 21 o’clock.Each diet and environmental conditions were similar Nasogastric tube to the farthest end of the stomach, the same time a day intake of 2600 kcal calorie content of standard mixed food.From the beginning of the 18-hour period, every 1 hour through the nasogastric tube sucked out 5 ~ 10ml stomach contents and measured