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目的:探究瘦素、脂联素对脂肪肝胰岛素抵抗的影响机制。方法:采用健康Wistar大鼠,随机分为正常对照组、实验组。实验组采用高脂饮食加白酒灌胃建立大鼠脂肪性肝炎模型。通过观察脂肪肝大鼠血清瘦素(Leptin)、脂联素(APN)水平,探究瘦素、脂联素生理病理学特性。结果:实验组大鼠第10周,瘦素水平明显高于对照组(P<0.01),脂联素水平明显低于对照组(P<0.01)。结论:脂肪肝病患者存在高瘦素血症、低脂联素血症,以致肝脏摄取脂肪增加,加速肝脏脂变、炎症及纤维化的发生。
Objective: To investigate the effect of leptin and adiponectin on fatty liver insulin resistance. Methods: Healthy Wistar rats were randomly divided into normal control group and experimental group. The experimental group using high-fat diet plus white wine gavage model of steatohepatitis in rats. By observing the levels of serum leptin and adiponectin (APN) in rats with fatty liver, the physiological and pathological characteristics of leptin and adiponectin were explored. Results: The leptin level in the experimental group was significantly higher than that in the control group (P <0.01) and the level of adiponectin in the experimental group was significantly lower than that in the control group (P <0.01). Conclusion: Patients with fatty liver disease have hyperlipidemia and hypoadiponectinemia, resulting in increased liver fat intake and accelerated hepatic steatosis, inflammation and fibrosis.