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随着DNA快速定序技术的发展,第一个真核细胞基因结构的测定揭示了一个使人意想不到的及费解的问题。原核细胞基因的编码顺序是连续的,而真核细胞的编码顺序是被插入的非编码顺序所分离。当然,这个难题是关于真核基因的镶嵌编制的意义。最有希望的解说是由Walter Gilbert于1978年提出的看法,他给编码顺序组提出了实用的及易被接受的术语称“表达子”,对非编码碱基的插入顺序称“内在子”。他论证表达子/内在子结构可能
With the rapid DNA sequencing technology, the first eukaryotic gene structure assay revealed an unexpected and convoluted problem. The coding sequence of prokaryotic genes is contiguous, whereas the coding sequence of eukaryotic cells is separated by the inserted non-coding sequence. Of course, this dilemma is about the significance of the mosaic of eukaryotic genes. The most promising commentary is the one put forward by Walter Gilbert in 1978. He proposed practical and readily accepted terms for the coding sequence group called “expressors.” The order of insertion of non-coding bases is called “introns” . He argued that the expression / inner substructure may be