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目的探讨C-12多肿瘤标志物蛋白芯片检测系统对鉴别附件肿块良恶性质的价值。方法采用C-12多肿瘤标志物蛋白芯片检测系统定量检测130例附件肿块患者(恶性组60例,良性组70例)和100例健康女性血清中的12种肿瘤标志物:AFP、CA125、CA199、CEA、CA153、CA242、Ferritin、β-HCG、NSE、HGH、f-PSA和PSA,评价其诊断价值。结果 CA125、CA199、CA242和CEA在恶性组中的阳性率显著高于良性组及健康对照组(P﹤0.05);其余标志物的表达在各组差异均无统计学意义(P﹥0.05)。联合检测CA125+CA199+CA242+CEA可提高对卵巢恶性肿瘤诊断的灵敏性和准确性。结论 C-12多肿瘤标志物蛋白芯片检测系统是辅助鉴别附件肿块良恶性质的有效方法之一,可提高卵巢恶性肿瘤诊断的灵敏性和准确性,有助于指导临床治疗。
Objective To investigate the value of C-12 multi-tumor marker protein chip detection system in differentiating benign and malignant features of accessory mass. Methods A total of 12 tumor markers, including AFP, CA125 and CA199, were quantitatively detected in 130 cases of accessory mass (60 cases in malignant group, 70 cases in benign group) and 100 healthy women by C-12 multi-tumor marker protein chip detection system. , CEA, CA153, CA242, Ferritin, β-HCG, NSE, HGH, f-PSA and PSA. Results The positive rates of CA125, CA199, CA242 and CEA in malignant group were significantly higher than those in benign group and healthy control group (P <0.05). There was no significant difference in other markers between the groups (P> 0.05). Combined detection of CA125 + CA199 + CA242 + CEA can improve the sensitivity and accuracy of the diagnosis of ovarian cancer. Conclusion The C-12 multi-tumor marker protein chip detection system is an effective method to identify benign and malignant features of accessory mass. It can improve the sensitivity and accuracy of ovarian cancer diagnosis and help guide the clinical treatment.