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目的：探讨抗抑郁药对功能性消化不良（ＦＤ）患者情绪障碍的疗效。方法：分别对２４例健康人和２４例ＦＤ病人进行汉密尔顿抑郁量表（ＨＡＭＤ）、汉密尔顿焦虑量表（ＨＡＭＡ）和症状自评量表（ＳＣＬ９０）评分；用抗抑郁药，５羟色胺再摄取抑制剂（ＳＳＲＩ）盐酸氟西汀（百忧解）、帕罗西丁（赛尔特）治疗２４例ＦＤ病人，疗程均为８周，治疗后再进行上述量表评分。结果：ＦＤ患者和正常人的三种量表（ＨＡＭＤ、ＨＡＭＡ、ＳＣＬ９０）评分对比，均显示ＦＤ患者的精神和躯体症状与正常人之间存在着显著差异（ｐ＜０００１）；而在日夜变化和精神病理上，差异无显著性；ＦＤ病人接受抗抑郁药治疗８周后，前后评分对比，患者的精神和躯体症状均有明显改善。结论：提示ＦＤ患者普遍存在抑郁和焦虑情绪，用抗抑郁药治疗ＦＤ能显著改善患者的症状，包括精神和躯体两方面的症状
Objective: To investigate the effect of antidepressants on mood disorders in patients with functional dyspepsia (FD). Methods: The Hamilton Depression Inventory (HAMD), Hamilton Anxiety Scale (HAMA) and Symptom Checklist 90 (SCL-90) were scored in 24 healthy individuals and 24 FD patients respectively. The antidepressants, 5-HT Reuptake inhibitor (SSRI) fluoxetine hydrochloride (Prozac), paroxetine (Celtic) treatment of 24 cases of FD patients, the course of treatment were 8 weeks after treatment, then the above scale score. Results: The comparison of the three scales of HAMD, HAMA and SCL90 showed that there was a significant difference (P <0001) between the mental and physical symptoms of FD patients and normal subjects. However, no significant difference was found in the changes of day and night and in the psychopathology. FD patients treated with antidepressants for 8 weeks had significantly improved mental and physical symptoms compared with before and after treatment. Conclusions: It is suggested that depression and anxiety generally exist in FD patients. Treatment of FD with antidepressants can significantly improve the symptoms of the patients, including both mental and physical symptoms