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目的:观察临终期胃癌患者血液生化指标的变化和生存期的关系。方法:回顾并分析我院2012年1月~2014年1月接收的73例发生院内死亡的胃癌患者的血生化指标变化及SOFA评分,并选取其中有完整死亡前随访资料的40例患者作为对照组,筛选出具备统计学的意义的生化指标,并将其数值转换成分数,相加之后得到每一例患者的生化评分,然后将生化评分和SOFA评分相加即为每例患者的预后评分。根据预后评分的分值大小将试验组患者分为两组:A组<20分,B组>20分,然后进行生存分析。结果:影响生存时间的主要指标有:AST、T一B I L、UREA、LDH、CK、UA以及HBDH;B组评分>20分的比例要显著高于A组(P<0.05);而B组的生存率则显著低于A组(P<0.05);预后评分与生存时间存在着直线相关的关系(P<0.05)。结论:根据本组临床资料而建立的评分办法效果显著,在对胃癌临终患者的生存风险进行评估时,值得推广、运用。
Objective: To observe the changes of blood biochemical markers and the relationship with survival in patients with terminal gastric cancer. Methods: The biochemical indexes and SOFA scores of 73 patients with natal inpatients admitted to our hospital from January 2012 to January 2014 were retrospectively analyzed. Forty patients with complete pre-death follow-up data were selected as control Groups were screened for biochemical indicators of statistical significance and their values were converted to fractions. Biochemical scores were obtained for each patient after addition, and biochemical scores and SOFA scores were added to give the prognostic score for each patient. Patients in the experimental group were divided into two groups based on the score of the prognostic score: group A <20 and group B> 20, and then the survival analysis was performed. Results: The main indexes affecting the survival time were: AST, T-BIL, UREA, LDH, CK, UA and HBDH; the score of group B> 20 was significantly higher than that of group A The survival rate was significantly lower than that of group A (P <0.05). There was a linear correlation between prognostic score and survival time (P <0.05). Conclusion: The scoring method established based on the clinical data of this group has a significant effect. It is worth popularizing and applying to evaluate the survival risk of patients with terminal cancer of the stomach.