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目的探讨对药物罕见不良反应的预防及应对措施。方法对我院收治的重症肌无力合并癫痫运动性发作应用溴吡斯的明联合卡马西平治疗后出现严重心动过缓1例的临床资料进行回顾性分析。结果患者患有重症肌无力合并部分性发作癫痫故应用溴吡斯的明60mg,3次/d联合卡马西平100mg,2次/d口服抑制胆碱酯酶活性及抗癫痫治疗,用药后2d出现严重心动过缓,最低心室率达37次/min,停用卡马西平1d后心率恢复致60～70次/min。结论对有相近不良反应的药物联合应用时应慎重,特别是存在相关基础疾病的患者更应提高警惕。
Objective To explore the prevention and treatment of rare adverse drug reactions. Methods A retrospective analysis was performed on one case of severe bradycardia after treatment with megestrol and carbamazepine for treatment of myasthenia gravis combined with seizures in our hospital. Results Patients with myasthenia gravis combined partial seizure epilepsy so the application of pyridostigmine 60mg, 3 times / d combined with carbamazepine 100mg, 2 times / d oral administration of cholinesterase activity and anti-epileptic treatment, 2d after treatment Severe bradycardia occurred, the minimum ventricular rate of 37 beats / min, 1d after the withdrawal of carbamazepine heart rate recovery caused by 60 to 70 beats / min. Conclusions It should be used with caution in the joint application of drugs with similar adverse reactions. In particular, patients with underlying underlying diseases should be more vigilant.