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目的:探讨研究纳洛酮在治疗新生儿缺氧缺血性脑病的疗效。方法:收集新生儿科2005～2010年治疗的中重度HIE56例。将其分为观察组32例,对照组24例,对照组采用常规的支持治疗及对症处理,观察组在常规治疗的基础上给予纳洛酮静滴。结果:观察组临床恢复情况好于对照组,观察组总有效率87.5%;对照组总有效率70.8%,2组比较有显著性差异(P<0.01)。结论:纳洛酮治疗新生缺氧缺血性脑病效果显著,纳洛酮治疗新生儿缺氧缺血性脑病可使临床症状持续时间缩短,减轻中重度新生儿缺氧缺血性脑病的并发症,减少后遗症,降低死亡率。
Objective: To investigate the efficacy of naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods: Fifty-five patients with moderate-severe HIE who were treated in neonatology from 2005 to 2010 were collected. The patients were divided into observation group (32 cases) and control group (24 cases). The control group received routine supportive and symptomatic treatment. The observation group received naloxone intravenously on the basis of routine treatment. Results: The clinical recovery of the observation group was better than that of the control group. The total effective rate was 87.5% in the observation group and 70.8% in the control group. There was significant difference between the two groups (P <0.01). Conclusion: Naloxone is effective in treating neonatal hypoxic-ischemic encephalopathy. Naloxone treatment of neonatal hypoxic-ischemic encephalopathy can shorten the duration of clinical symptoms and reduce the complications of hypoxic-ischemic encephalopathy in moderate-severe neonates , Reduce sequelae, reduce mortality.