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目的 寻找和开发治疗脑膜瘤的有效药物。方法 应用裸鼠肾包膜下法建立人脑膜瘤动物模型。采用三种不同剂量的米非司酮在动物模型建立后皮下注射用药 ,2 8天后将各组间肿瘤生长率作统计学分析。原始标本用免疫组化SP法检测孕激素受体 (PR)。结果 中剂量组和高剂量组与对照组之间有显著性差异 (P <0 0 1) ,低剂量组与对照组之间无显著性差异 (P >0 0 5 )。 7例标本经免疫组化检测 ,4例PR阳性 ,但米非司酮对PR阴性组与PR阳性组的作用差异不显著 (P >0 0 5 )。结论 米非司酮对人脑膜瘤有明显的生长抑制作用 ,可能是通过阻断PR或其他受体而抑制了脑膜瘤细胞的增殖。
Objective To find and develop effective drugs for the treatment of meningioma. Methods The animal model of human meningioma was established by subcutaneous subrenal transplantation in nude mice. Three different doses of mifepristone were injected subcutaneously after the animal model was established. Twenty-eight days later, the tumor growth rate of each group was statistically analyzed. The original specimens were tested for progesterone receptor (PR) by immunohistochemical SP method. Results There was a significant difference between the middle dose group and the high dose group and the control group (P <0.01). There was no significant difference between the low dose group and the control group (P> 0.05). Seven of the specimens were detected by immunohistochemistry and four of them were positive for PR. However, the effect of mifepristone on PR-negative group and PR-positive group was not significant (P> 0.05). Conclusion Mifepristone has obvious growth inhibitory effect on human meningiomas, which may inhibit the proliferation of meningioma cells by blocking PR or other receptors.