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六十年代已广泛采用镇痛性麻醉药进行麻醉,而且又引进了先进的免疫测定方法,同时还发现使用大剂量镇痛性麻醉药比吸入性麻醉药能更有效地抑制手术的应激反应。一、内啡肽系统-受体和配体各种不同应激反应能引起机体特殊部位分泌多种内源性阿片肽与不同受体结合。经不断努力目前已分离出阿片受体或内源性配体。这些复杂的受体已分为各亚型作为药物的靶标,例如作用于背侧角的各位置就能增强镇痛作用。所以有必要进一步了解内源性镇痛和激素释放的过程。七十年代Gilbert和Martin提出阿片受体的初步设想,例如被吗啡激活的阿片受体产生镇痛、瞳孔散大和呼吸抑制等作用,即
In the 1960s, analgesic anesthetics were widely used for anesthesia and advanced immunoassays were introduced. It was also found that the use of high-dose analgesic anesthetics was more effective than inhaled anesthetics in suppressing the surgical stress response . First, the endorphin system - Receptors and ligands A variety of different stress reactions can cause a variety of endogenous opioid peptides secreted by different parts of the body to bind to different receptors. After continuous efforts, opioid receptors or endogenous ligands have been isolated. These complex receptors have been subdivided into subtypes as targets for drugs, for example analgesic effects at various locations on the dorsal horn. So it is necessary to further understand the process of endogenous analgesia and hormone release. Seventies Gilbert and Martin put forward the initial idea of opioid receptors, such as morphine-activated opioid receptor analgesia, mydriasis and respiratory depression and so on, that is