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目的观察氯沙坦对糖尿病合并高血压患者胰岛素抵抗的影响。方法对30例糖尿病合并高血压患者测血糖、血浆胰岛素及血胆固醇(TC)、甘油三酯(TG)、游离脂肪酸(FFA),服用氯沙坦50～100mg/d,第4周时重复血糖、血浆胰岛素及上述检查,计算自我平衡模型分析法(HOMA)胰岛素抵抗指数(HOMA-IR),比较治疗前后差异有无显著性。结果氯沙坦治疗后糖尿病合并高血压患者血浆胰岛素及HOMA-IR均较服药前明显下降(P<0.05)。结论氯沙坦可改善糖尿病合并高血压患者胰岛素抵抗。
Objective To observe the effect of losartan on insulin resistance in patients with diabetes mellitus and hypertension. Methods Blood glucose, plasma insulin and blood cholesterol (TC), triglyceride (TG) and free fatty acid (FFA) were measured in 30 patients with diabetes mellitus and 50 ~ 100 mg / d losartan. , Plasma insulin and the above examination, calculate the HOMA-insulin resistance index (HOMA-IR), and compare the difference between before and after treatment. Results After treatment with losartan, plasma insulin and HOMA-IR of diabetic patients with hypertension were significantly lower than those before treatment (P <0.05). Conclusion Losartan can improve insulin resistance in patients with diabetes mellitus and hypertension.