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目的了解某高校医院抗高血压药使用现状。方法对2008年1—6月在我院就诊的高血压患者的处方进行分析,分别就降压药种类、使用率、用药方案进行统计。结果使用了6类降压药,钙离子拮抗剂在降压治疗中占主导地位,使用率为50.74%,其次为血管紧张素Ⅱ受体阻滞剂、血管紧张素转换酶抑制剂,使用率分别为25.18%和23.16%,联合用药率为35.11%。<60岁者与≥60岁者在治疗方案选择上差异无统计学意义(P>0.05)。<60岁者与≥60岁者在辅以阿司匹林治疗上差异无统计学意义(P>0.05)。结论某高校医院抗高血压药物选择种类符合《中国高血压防治指南》(2005),治疗方案选择以单一用药为主,不符合JNC-7中联合用药为主的原则,这是本组资料中高血压有效控制率低的原因之一;另外,临床医生应重视非甾体抗炎药在高血压患者中使用所引起的胃肠道副作用。
Objective To understand the use of antihypertensive drugs in a university hospital. Methods The prescriptions of hypertensive patients treated in our hospital from January to June in 2008 were analyzed, and the types of antihypertensive drugs, usage rate and medication regimen were analyzed respectively. Six antihypertensive drugs were used in the study. Calcium antagonists dominates the antihypertensive treatment with a rate of 50.74%, followed by angiotensin Ⅱ receptor blockers, angiotensin converting enzyme inhibitors, Respectively, 25.18% and 23.16%, combined rate was 35.11%. There was no significant difference in treatment options between patients <60 years and those ≥60 years (P> 0.05). There was no significant difference in the treatment of aspirin between 60-year-old and 60-year-old (P> 0.05). Conclusion The selection of antihypertensive drugs in a university hospital is in line with the Guide to Prevention and Treatment of Hypertension in China (2005). The choice of treatment option is mainly based on single drug, which is not in line with the principle of combination therapy in JNC-7. In addition, clinicians should pay attention to non-steroidal anti-inflammatory drugs in hypertensive patients caused by gastrointestinal side effects.