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目的评价胺碘酮与依那普利联合治疗阵发性心房颤动(房颤)的临床疗效。方法将129例阵发性房颤随机分为胺碘酮组(Ⅰ组,n=64)和胺碘酮联合依那普利组(Ⅱ组,n=65),治疗随访时间为1年,研究终点为房颤发作。比较两组治疗前、治疗后的左心房内径。计算两组治疗后窦性心律维持率。结果两组患者治疗前后左心房内径比较:治疗前分别为(35.21±1.76)mm、(35.84±1.69)mm,治疗后分别为(38.76±2.14)mm、(36.27±1.91)mm,治疗后II组患者左房内径明显小于I组。两组患者窦性心律维持率的比较:治疗结束时,I组患者窦性心律维持率为62.3%,II组患者窦性心律维持率80.6%,两组患者比较有显著性差异。结论胺碘酮与依那普利联合治疗阵发性房颤维持窦性心律的疗效优于单用胺碘酮,对延缓左心房扩大有一定作用。
Objective To evaluate the clinical efficacy of amiodarone combined with enalapril in the treatment of paroxysmal atrial fibrillation (AF). Methods 129 patients with paroxysmal atrial fibrillation were randomly divided into amiodarone group (n = 64) and amiodarone plus enalapril group (n = 65). The follow-up time was 1 year, The study endpoint was atrial fibrillation. The left atrial diameter of the two groups before and after treatment were compared. Calculate the maintenance rate of sinus rhythm after treatment in both groups. Results Before and after treatment, the left atrial diameter of the two groups were (35.21 ± 1.76) mm and (35.84 ± 1.69) mm respectively, and were (38.76 ± 2.14) mm and (36.27 ± 1.91) mm respectively The left atrium diameter was significantly smaller in group I than in group I. Comparison of maintenance rate of sinus rhythm between the two groups: At the end of treatment, the maintenance rate of sinus rhythm was 62.3% in group I and 80.6% in group II, there was a significant difference between the two groups. Conclusion Amiodarone combined with enalapril treatment of paroxysmal atrial fibrillation to maintain sinus rhythm better than single amiodarone, to delay the expansion of the left atrium has a role.