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目的探讨中年人群血清瘦素水平与代谢综合征(MS)及其组分的关系。方法对345例“宫内发育与成人疾病”研究队列人群(男184例、女161例,年龄46～53岁)的身高、体重、血压、血脂、血糖、胰岛素及血清瘦素进行测定,采用稳态模式评估法计算胰岛素抵抗指数。根据2005年国际糖尿病联盟(IDF)关于 MS 的定义进行诊断。结果该群体中心性肥胖、高甘油三酯、低的高密度脂蛋白胆固醇(HDL-C)、高血糖、高血压及 MS 检出率分别为53.0%、47.5%、34.2%、26.7%、33.9%和31.9%;女性血清瘦素水平几何均数为男性的2.9倍,随着血清瘦素浓度的升高,该人群的MS 及组分异常检出率明显上升,除男性组 HDL-C 指标外,不同血清瘦素水平与 MS 及组分比较均有显著统计学意义(P<0.05),且随着代射异常组分个数的增多血清瘦素水平呈上升趋势,呈显著正相关(P<0.001)。结论该人群的血清瘦素水平与 MS 及组分密切相关,提示高瘦素血症可能是 MS的一个新成分,可作为筛查 MS 及相关疾病的一个指标。
Objective To investigate the relationship between serum leptin levels and metabolic syndrome (MS) and its components in middle-aged population. Methods The height, weight, blood pressure, blood lipids, blood glucose, insulin and serum leptin of 345 cohorts (184 males and 161 females, aged 46-53 years) in the cohort of “intrauterine development and adult diseases” , Using the steady state model to calculate the insulin resistance index. According to the 2005 International Diabetes Federation (IDF) on the definition of MS diagnosis. Results The detection rates of central obesity, high triglyceride, low-density lipoprotein cholesterol (HDL-C), high blood sugar, high blood pressure and MS were 53.0%, 47.5%, 34.2%, 26.7% and 33.9 % And 31.9%, respectively. The geometric mean leptin level in women was 2.9 times higher than that in males. With the increase of serum leptin level, the detection rate of MS and component abnormalities in this population increased significantly. Except male HDL-C In addition, serum leptin levels were significantly different from MS and its components (P <0.05), and the levels of serum leptin increased with the increase of the number of abnormal progenitor cells (P <0.05) P <0.001). Conclusions Serum leptin level in this population is closely related to MS and its components, suggesting that hyperleptinemia may be a new component of MS and could be used as an index in screening MS and related diseases.