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胆汁中游离的钙离子浓度对于胆结石的形成有着重要的作用,虽然总钙浓度较高,如能降低游离钙离子的浓度,也会减少胆结石的生成。胆汁中的胆盐等有降低游离的钙离子的作用。目前国内外采用口服鹅脱氧胆酸及试用熊脱氧胆酸治疗结石症,有人研究了口服后对人体功能的影响,有人从动物实验说明在服用鹅脱氧胆酸剂量较大时反而有增加结石的情况。我们从胆汁酸盐与钙的作用方面进行研究,拟为临床上筛选药物提供一些依据。已有文献报导了甘氨胆酸与钙的作用,我们用钙离子选择电报试验了五种胆汁酸盐与钙的作
Free calcium concentration in bile has an important role in the formation of gallstones, although the total calcium concentration, such as reducing the concentration of free calcium ions, will also reduce the formation of gallstones. Bile in the bile salt, etc. to reduce the role of free calcium ions. At home and abroad using oral chenodeoxycholic acid and ursodeoxycholic acid test for the treatment of stone disease, it was studied after oral administration of human function, some people from animal experiments show that when taking a large dose of chenodeoxycholic acid but have increased stone Happening. We study the role of bile salts and calcium, to provide some basis for the clinical screening of drugs. It has been reported in the literature that glycocholic acid acts with calcium, and we tested five bile salts and calcium with calcium ion selective telegraphy