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目的观察氯胺酮（Ｋ）单用及与它药合用对血浆心钠素（ＡＮＰ）、醛固酮（Ａ）浓度的影响。方法腹腔注射给药，待小鼠翻正反射消失后１ｍｉｎ断头取血，放免法测定ＡＮＰ和Ａ。结果Ｋ组ＡＮＰ、Ａ显著高于ＮＳ组（Ｐ＜０．０１）。在ＡＮＰ，Ｋ＋可乐定组高于Ｋ组（Ｐ＜０．０１）；Ｋ＋普鲁卡因组低于Ｋ组（Ｐ＜０．０１）而与ＮＳ组接近（Ｐ＞０．０５）；Ｋ＋吗啡组、Ｋ＋安定组、Ｋ＋羟丁酸钠组和Ｋ＋依托咪酯组均与Ｋ组相似（Ｐ＞０．０５）。在Ａ，各合用药组均高于ＮＳ组（Ｐ＜０．０１，Ｐ＜０．０５）而低于Ｋ组，但Ｋ＋普鲁卡因组、Ｋ＋依托咪酯组与Ｋ的差别无统计学意义（Ｐ＞０．０５）。结论Ｋ可升高小鼠血浆ＡＮＰ、Ａ浓度，合用药物多可改变这一效应
Objective To observe the effect of Ketamine (K) alone and in combination with it on plasma ANP and aldosterone (A) concentrations. Method of intraperitoneal injection, until the mouse righting reflex disappeared 1min after decapitation bleeding, radioimmunoassay ANP and A determination. Results The ANP and A in group K were significantly higher than those in group NS (P <0.01). Compared with K group, K + procaine group was lower than K group (P <0.01) and close to NS group (P> 0.05) The morphine group, K + diazepam group, K + hydroxybutyrate group and K + etomidate group were similar to K group (P> 0.05). In A group, the combined medicine group was higher than NS group (P <0.01, P <0.05) and lower than K group, but K + procaine group, K + etomidate group and K was no statistical difference Significance (P> 0.05). Conclusion K can increase plasma ANP, A concentration, combined with more drugs can change this effect