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本研究结果表明:失血后犬动脉血浆游离氨基酸总浓度明显增加,氨基酸谱发生显著的时相性改变。21种游离氨基酸有17种高于失血前水平,在失血后3～4h先后达最高值,至5h仍高于失血前水平。门冬酰胺、谷氨酰胺、异亮氨酸、亮氨酸、酪氨酸及苯丙氨酸在失血后5h仍维持最高水平。精氨酸与丝氨酸水平下降,精氨酸在失血后4～5h急剧下降。苏氨酸、磷酸丝氨酸变化不明显。增长率最明显的是牛磺酸,失血后3h,达失血前的290%。浓度增加的绝对值是丙氨酸最高,支/芳比值无明显变化。动脉血丙酮酸和乳酸在失血后3h达最高值,以后乳酸维持在高水平上,而丙酮酸开始下降。剩余乳酸在失血后4～5h增高最明显。
The results of this study indicate that the total concentration of free amino acids in the plasma of canine arteries increases significantly after blood loss, and the amino acid profile changes significantly with time. Twenty-one of the 21 free amino acids were higher than the pre-bleeding level and reached the highest value at 3 to 4 h after blood loss, and remained higher than the pre-bleeding level at 5 h. Asparagine, glutamine, isoleucine, leucine, tyrosine and phenylalanine remained at their highest levels 5 hours after blood loss. The levels of arginine and serine decreased, and arginine decreased rapidly 4 to 5 hours after blood loss. Threonine and phosphoserine did not change significantly. Taurine is the most noticeable growth rate, accounting for 290% of blood loss 3 hours after blood loss. The absolute value of the increase in the concentration is the highest in alanine, and there is no significant change in the ratio of the branch to the aromatic. Arterial blood pyruvate and lactic acid peaked at 3h after blood loss, after which lactic acid remained at a high level and pyruvate began to decline. The remaining lactic acid increased most significantly at 4 to 5 h after blood loss.