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研究表明 ,在高脂等各种刺激因子及多种细胞因子作用下 ,动脉内膜细胞外基质 (extracellularmatrix ,ECM )成分沉积、内膜增厚及中膜平滑肌细胞迁移增生 ,最终导致动脉粥样硬化 (AS)形成。近 10余年来在研究有关ECM合成和降解的代谢平衡中基质金属蛋白酶 (matrixmetalloprotein
Studies have shown that the deposition of extracellular matrix (ECM) components, intimal thickening and mesangial smooth muscle cell migration and proliferation under the action of various stimulating factors such as hyperlipidemia and various cytokines eventually lead to atherosclerosis Hardening (AS) formation. In the past 10 years in the study of ECM synthesis and degradation of the metabolic balance of matrix metalloproteinases (matrixmetalloprotein