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氨甲喋呤(MTX)鞘内注射是防治中枢神经系统(CNS)白血病的重要手段,而发生神经毒性的报道较少。现将我院见到的6例报告如下。临床资料 6例患者均为女性,年龄11～50岁。急淋(ALL)4例,急单(M_5)和早幼(M_3)各1例。均经诱导缓解化疗达完全缓解(CR)标准。MTX注射方法:用地塞米松5mg(1ml)溶解MTX10mg椎管内缓慢推注10min。反应出现时间:5例为注射后5h出现,1例为12h时出现。反应的表现为:高热、头痛、恶心、呕吐、神志恍忽、颈项强直。处理措施:20％甘露醇快
Intrathecal methotrexate (MTX) intrathecal injection is an important means of prevention and treatment of central nervous system (CNS) leukemia, and less neurotoxicity has been reported. Now in our hospital to see the 6 cases are as follows. Clinical data 6 patients were female, aged 11 to 50 years. 4 cases of acute lymphoblastic leukemia (ALL), 1 case of emergency (M_5) and young (M_3). Induction of remission chemotherapy for complete remission (CR) standards. MTX injection method: Dexamethasone 5mg (1ml) dissolved MTX10mg slowly push the spinal canal 10min. Response time: 5 cases occurred 5h after injection, 1 case occurred when 12h. Response to the performance: high fever, headache, nausea, vomiting, delirious, neck stiffness. Action: 20% mannitol fast