鼠伤寒沙门氏菌/微粒体诱变试验对73种化学物质的致突变性测定

• 作 者: 曾立成 张效良 胡红一
• 机 构: 南充医专病理教研室,南充医专病理教研室,南充医专病理教研室,
• 出 处: 肿瘤防治研究
• 发表日期: 1983年03期
• 关键词: 鼠伤寒沙门氏菌 突变性 微粒体 化学物质 诱变 诱变剂量 致突变物 反应曲线 致癌物 Ames

自Ames全面介绍鼠伤寒沙门氏菌/微粒体诱变试验(即Ames试验)方法以来,此法已被广泛用于测定人类接触的化学物质的潜在致癌与致突变性。由于其具有快速、简易、经济、特别是准确性高的特点,被认为是快速筛测化学致癌物的较优方法之一。我室用此法筛测了以医药和实验室试剂为主的73种化学物质的致突变性,现报告如下。

Since Ames comprehensively introduced the S. typhimurium/microsomal mutagenesis test (ie, the Ames test) method, this method has been widely used to determine the potential carcinogenicity and mutagenicity of human exposure chemicals. Because of its characteristics of rapidity, simplicity, economy, and especially high accuracy, it is considered to be one of the best methods for rapid screening of chemical carcinogens. My laboratory used this method to screen the mutagenicity of 73 chemical substances mainly based on medicines and laboratory reagents. The report is as follows.