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对２９６例矽肺患者分组进行了由汉防己甲素（汉甲）、克矽平、抗矽一号＋柠檬酸铝（柠铝）组成的３种联合用药方案的矽肺治疗，在疗前及第１，３，６疗程后测定血清铜蓝蛋白（Ｃｐ）、超氧化物岐化酶（ＳＯＤ）和ＩｇＧ含量。同时观察对照病人１４４例。发现三项指标在治疗后有总体下降趋势。ＳＯＤ在治疗中有波动，即第１疗程后下降，第３疗程后上升，第６疗程后又回落。Ｃｐ、ＳＯＤ及ＩｇＧ的下降与药物的临床疗效符合。表明Ｃｐ、ＳＯＤ及ＩｇＧ是较为理想的生化指标。检验过程中的质量控制及统计分析时的标化处理，是生化指标在矽肺疗效评价应用中的关键
A total of 296 patients with silicosis were divided into three groups: tetrandrine, trimethoprim-sulfamethoxazole, azithromycin, Serum levels of ceruloplasmin (Cp), superoxide dismutase (SOD) and IgG were measured after 1, 3 and 6 courses of treatment. At the same time observe the control patients in 144 cases. The three indicators were found to have an overall downward trend after treatment. SOD in the treatment of fluctuations, that decline after the first course of treatment, after the rise of the third course of treatment, after the 6th course and down again. The decrease of Cp, SOD and IgG is consistent with the clinical efficacy of the drug. It shows that Cp, SOD and IgG are the ideal biochemical indicators. The quality control in the inspection process and the standardization in the statistical analysis are the key points of the application of biochemical indexes in the evaluation of silicosis efficacy