雌激素受体、表皮生长因子受体在乳腺癌中表达的意义探讨

• 作 者: 郑建涛 林永 曾金华 刘景丰
• 机 构: 福建医科大学附属第一医院普外科,福建医科大学附属第一医院普外科,福建医科大学附属第一医院普外科,福建医科大学附属第一医院普外科
• 出 处: 福建医药杂志
• 发表日期: 1998年03期
• 关键词: 乳腺癌 ER EGFR 免疫组化

目的：探讨雌激素受体（ER）、表皮生长因子受体（EGFR）在乳腺癌中表达的意义。方法：应用免疫组化SP法。结果：ER、EGFR蛋白阳性表达率分别为58．1％（54／93）、39．8％（37／93），明显高于乳腺良性病变的4．2％（1／24）、8．7％（2／23）和正常乳腺组织（0％）（P＜0．01）。乳腺癌中ER以浸润性导管癌、硬癌阳性率最高，EGFR以浸润性导管癌、硬癌、单纯癌阳性率最高，小叶原位癌、粘液腺癌均为阴性。ER、EGFR表达与乳腺肿瘤大小、淋巴结转移、分化程度明显相关（P＜0．05，P＜0．05、P＜0．01）。ER阴性者的淋巴结转移率为66．7％（36／54），高于ER阳性者的33．3％（18／54）（P＜O．05），EGFR阳性的淋巴结转移率为7O．4％（38／54），高于EGFR阴性的淋巴结转移率29．6％（16／54）。结论：ER、EGFR阴性低淋巴结转移率与乳腺癌淋巴结转移有关，可作为乳腺癌预后分析和估计的参考。 Objective: To investigate the significance of estrogen receptor (ER) and epidermal growth factor receptor (EGFR) expression in breast cancer. Methods: Immunohistochemical SP method was used. RESULTS: The positive expression rates of ER and EGFR proteins were 58.1% (54/93) and 39.8% (37/93), respectively, which was significantly higher than that of 4.2% (1/24) of benign breast lesions. 7% (2/23) and normal breast tissue (0%) (P<0.01). The positive rate of invasive ductal carcinoma and hard cancer in ER was highest in breast cancer. The positive rate of EGFR was the highest in invasive ductal, hard, and simple cancers. The lobular carcinoma in situ and mucinous adenocarcinoma were all negative. The expression of ER and EGFR was significantly correlated with breast tumor size, lymph node metastasis and differentiation (P<0.05, P<0.05, P<0.01). ER negative lymph node metastasis rate was 66.7% (36/54), higher than ER positive 33.3% (18/54) (P