肝硬化患者腹水培养阳性结果的病原菌分布及耐药性分析

• 作 者: 刘丹丹 张小冲 李金龙 蔡永冉 张洁莉
• 机 构: 河北省邢台市人民医院检验科 054000;河北省邢台市人民医院检验科 054000;河北省邢台市人民医院检验科 054000;河北省邢台市人民医院检验科 054000;邢台医学高等专科学校第二附属医院
• 出 处: 健康女性
• 发表日期: 2021年16期
• 关键词: Cirrhosis Ascites Pathogenic bacteria Drug resistance

目的 分析我院肝硬化患者腹水培养阳性标本中的病原菌分布及耐药情况.方法 对我院2016年1月至2020年12月间所送检肝硬化患者的901例腹水标本进行细菌培养、病原菌鉴定及药敏试验,并使用WHONET5.6软件进行数据分析.结果 共有99例腹水培养阳性,分离菌株99株,阳性率为10.99％.其中革兰氏阴性菌为52株,占52.53％,主要以大肠埃希菌为主,检出率为30.30％.革兰氏阳性菌47株,占47.47％,主要以凝固酶阴性葡萄球菌为主,检出率为22.22％.大肠埃希菌对氨苄西林、哌拉西林和头孢唑林耐药“,”Objective To analyze the bacterial distribution and antibiotic resistance of pathogenic bacterial in positive ascites culture samples from patients with cirrhosis in our hospital. Methods Bacterial culture, pathogen identification and drug sensitivity test were performed on 901 ascites samples from cirrhotic patients in our hospital from January 2016 to December 2020, and data analysis was performed using WHONET5.6 software. Results A total of 99 ascites were cultured positive and 99 strains were isolated, the positive rate was 10.99％. Among them, 52 strains were gram-negative bacteria, accounting for 52.53％, mainly escherichia coli, with a detection rate of 30.30％. 47 strains of Gram-positive bacteria, accounting for 47.47％, were mainly coagulase negative staphylococcus, the detection rate was 22.22％. Escherichia coli was resistant to ampicillin, piperacillin and cefazolin, but sensitive to carbapenems. Staphylococcus had higher drug resistance rate to penicillin and erythromycin, and was sensitive to linezolid, vancomycin and teicoranin. Conclusion There are many kinds of pathogenic bacteria in ascites culture of cirrhotic patients. The current research results show that escherichia coli and coagulase-negative staphylococcus are the main pathogens, and the detection rate of Gram-positive bacteria is on the rise. Through the correct and reasonable selection of antibacterial drugs, reduce the emergence of drug resistance bacteria, has important guiding significance for clinical drug use.