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目的：探讨细菌性阴道病( BV)对女性不孕的影响及其与抗精子抗体( ASAb)的关系。方法对980例女性不孕患者和876例正常妊娠妇女的阴道分泌物进行唾液酸苷酶检测，并采用酶联免疫吸附( ELISA)法对女性不孕患者血清进行AS-Ab检测，并对结果进行分析。结果女性不孕患者的唾液酸苷酶和ASAb阳性率分别为24.5%和12.8%，其阳性率明显高于正常妊娠妇女组(P<0.05)；唾液酸苷酶阳性组的AsAb阳性率为22.9%，显著高于唾液酸苷酶阴性组的9.5%，差异有统计学意义(P<0.05)。结论 BV和血清免疫不孕抗体ASAb可引起女性不孕，且BV与ASAb的产生有相关性，对女性不孕的诊断和治疗具有重要的指导意义。“,”Objective To explore the influence of bacterial vaginosis on female patients with infertility,and the relationship between bacterial vaginosis and anti-sperm antibody( AsAb) . Methods Vaginal secretions samples of female patients with 980 infertility and 876 pregnant women were collected and used to detect neuraminidase. Enzyme linked immunosorbent assay( ELISA) was used to deter-mine the levels of ASAb. Results The positive rates of neuraminidase and AsAb in female patients were 24. 5% and 12. 8% in 980 female patients with infertility,respectively. The positive rate was significantly higher than that of the control group(P <0. 05). The positive rate of AsAb(22. 9%) in BV positive groups was higher than that in BV negative groups(9. 5%,P < 0. 05). Conclusion Bacterial vaginosis and AsAb can affect women infertility,bacterial vaginosis and anti-sperm antibody,which have a cor-relation in occurrence of female infertility. They will provide important reference for diagnositic and treatment.