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研究转移相关蛋白CD4 4 V6 、PCNA在大肠癌中的表达与淋巴结转移的关系。 10 4例经手术切除D2、D3淋巴结清扫的大肠癌病例 ,按有无淋巴结转移分两组 ,采用免疫组化技术 (S -P法 )检测CD4 4 V6 、PCNA的表达。本组大肠癌中有淋巴结转移的 56例CD4 4 V6 、PCNA阳性率均为 75 0 % (42 /56 ) ,CD4 4 V6 、PCNA蛋白表达与大肠癌淋巴结转移有关 (P <0 0 5)。CD4 4 V6 、PCNA蛋白在大肠癌转移过程中起重要作用 ,并可作为预测大肠癌淋巴结转移的指标 ,其检测对指导临床治疗和估计预后有一定帮助
To study the relationship between the expression of metastasis associated protein CD4 (V4) V6 and PCNA in colorectal carcinoma and lymph node metastasis. 104 cases of colorectal cancer resected by D2, D3 lymph node dissection were divided into two groups according to the presence or absence of lymph node metastasis. The expression of CD4 4 V6 and PCNA was detected by immunohistochemistry (S-P method). The positive rate of PCNA in 56 cases with lymph node metastasis in colorectal cancer group was 75 0% (42/56). The expression of CD4 4 V6 and PCNA protein was correlated with lymph node metastasis in colorectal cancer (P 0.05). CD4 4 V6, PCNA protein plays an important role in the metastasis of colorectal cancer and can be used as an index to predict lymph node metastasis of colorectal cancer. The detection of CD4 4 V6 and PCNA may help to guide the clinical treatment and prognosis