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目的探讨培哚普利(PE)对高血压左室肥厚(LVH)消退及心肌复极离散的影响。方法高血压合并LVH患者45例应用PE治疗2年中,随访观察超声心动图LVH消退及心电图复极离散(QTd)的变化。结果与治疗前相比,治疗后观察期内,血压显著下降(P<0.01),LVH呈进行性消退(P<0.01),QTd明显缩短(P<0.01)。结论应用PE治疗高血压合并LVH全程观察期内,显著稳定降压的同时,可以使LVH消退,QTd缩短,心肌复极电稳定性增加。
Objective To investigate the effect of perindopril (PE) on regression of left ventricular hypertrophy (LVH) and myocardial repolarization in hypertensive patients. Methods Forty-five patients with hypertension and LVH were treated with PE for 2 years. Echocardiographic LVH regression and electrocardiogram repolarization dispersion (QTd) were observed. Results Compared with those before treatment, blood pressure decreased significantly (P <0.01), progressive regression of LVH (P <0.01) and QTd significantly shortened (P <0.01). Conclusions PE treatment of hypertension combined with LVH throughout the observation period, significantly stable antihypertensive at the same time, can make LVH subsided, QTd shortening, myocardial repolarization stability increased.