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目的 :据国内外文献综述一氧化氮合酶抑制剂与吗啡依赖和耐受的关系 ,为一氧化氮合酶抑制剂在吗啡戒断的临床治疗中提供依据。方法 :介绍一氧化氮影响吗啡戒断的原理及几种常见一氧化氮合酶抑制剂在大小鼠吗啡戒断综合征中的作用。结果 :一氧化氮参与了阿片类药物依赖和耐受的产生和发展。结论 :一氧化氮合酶抑制剂可有效治疗吗啡脱毒综合征 ,但也应充分考虑其负面作用
OBJECTIVE: To review the relationship between nitric oxide synthase inhibitor and morphine dependence and tolerance in domestic and foreign literature and provide a basis for the clinical treatment of morphine withdrawal by nitric oxide synthase inhibitor. Methods: The principle of nitric oxide affecting morphine withdrawal and the role of several common nitric oxide synthase inhibitors in morphine withdrawal syndrome in rats and mice were introduced. Results: Nitric oxide is involved in the generation and development of opioid dependence and tolerance. CONCLUSIONS: Nitric oxide synthase inhibitors are effective in treating morphine detoxification syndromes, but should also take full account of their negative effects