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目的 :探讨冠心病 (CHD)不同程度冠脉病变时胰岛素敏感性指数、血清脂质的变化及意义。方法 :2 9例CHD同时合并糖尿病的病人 ,按冠脉主要分支最大狭窄程度和斑块病变类型不同分为明显病变组 (SG)和轻度病变组 (MG) ,另取同期冠造正常非CHD者 16例为对照组 (CG)。测定各组空腹血糖、胰岛素和餐后 2小时血糖、胰岛素 ,胰岛素敏感指数 ,血清脂质水平。结果 :CHD同时合并糖尿病的病人各指标显著高于健康对照组 (P <0 .0 5 -0 .0 1) ,且冠脉明显病变组显著高于冠脉轻度病变组 (P <0 .0 5 )。结论 :上述各参数可能对于区分CHD冠脉病变程度具有预示价值 ,胰岛素抵抗的发生可严重影响冠脉病变的程度
Objective: To investigate the changes of insulin sensitivity index and serum lipids in coronary artery disease with different degrees of coronary heart disease (CHD) and its significance. Methods: Twenty-nine CHD patients with diabetes mellitus were divided into two groups according to the degree of major stenosis of coronary artery and the type of plaque. The patients with obvious disease (SG) and mild lesion (MG) 16 cases of CHD as control group (CG). Fasting blood glucose, insulin and 2 hours postprandial blood glucose, insulin, insulin sensitivity index and serum lipid levels were determined. Results: The indexes of CHD patients with diabetes mellitus were significantly higher than those of healthy controls (P <0.05-0.01), and the number of coronary lesions was significantly higher than that of mild coronary lesions (P <0.05). 0 5). CONCLUSIONS: The above parameters may have predictive value for differentiating the severity of CHD coronary artery disease. The occurrence of insulin resistance may seriously affect the degree of coronary artery disease