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目的观察全身应用卡铂、替尼泊苷和长春新碱(CTV)方案化疗加鞘内注射治疗脑脊液细胞学检查肿瘤细胞阳性的视网膜母细胞瘤(RB)患儿的疗效。方法6例患儿资料来自首都医科大学附属北京同仁医院2006年11月至2008年7月临床确诊为RB且治疗前行脑脊液细胞学检查发现肿瘤细胞者,对其进行6～9次CTV方案化疗加8～10次鞘内注射治疗,同时结合局部治疗,随访12～20个月,观察疗效。结果6例患儿均完成治疗,病情稳定,复查脑脊液细胞学检查均未发现肿瘤细胞,无复发及死亡。结论全身化疗加鞘内注射是对RB颅内转移有效的治疗方法,由于观察时间较短,长期疗效尚须行观察。
Objective To observe the curative effect of systemic chemotherapy with carboplatin, teniposide and vincristine (CTV) plus intrathecal injection on cerebrospinal fluid cytology in children with retinoblastoma (RB) positive for tumor cells. Methods Six cases of children with data from Beijing Tongren Hospital, Capital Medical University from November 2006 to July 2008 clinically diagnosed as RB and treatment of cerebrospinal fluid cytology before the detection of tumor cells who were 6 to 9 CTV regimen chemotherapy Plus 8 to 10 intrathecal injections, combined with local treatment, followed up for 12 to 20 months to observe the effect. Results All the 6 children were treated with stable disease. No tumor cells, no recurrence and death were found in the cytological examination of cerebrospinal fluid. Conclusion The systemic chemotherapy plus intrathecal injection is an effective treatment for RB intracranial metastasis. Because of the short observation time, the long-term curative effect still needs to be observed.