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目的比较奥美拉唑与雷尼替丁治疗胃食管反流病的临床疗效。方法选取井冈山市东上卫生院2010年2月—2016年2月收治的胃食管反流病患者180例,随机分为对照组和观察组,各90例。对照组患者给予雷尼替丁胶囊治疗,观察组患者采用奥美拉唑胶囊治疗,两组患者均持续治疗2个月。比较两组患者的临床疗效及不良反应发生情况。结果观察组患者临床疗效优于对照组,不良反应发生率低于对照组(P<0.05)。结论采用奥美拉唑治疗胃食管反流病的临床疗效优于雷尼替丁,其可更有效改善患者的临床症状及体征,且安全性好。
Objective To compare the clinical efficacy of omeprazole and ranitidine in the treatment of gastroesophageal reflux disease. Methods 180 cases of gastroesophageal reflux disease admitted to East Shanghai Hospital of Jinggangshan from February 2010 to February 2016 were randomly divided into control group and observation group, with 90 cases each. Patients in the control group were treated with ranitidine capsules. Patients in the observation group were treated with omeprazole capsules, and both groups were treated for 2 months. The clinical efficacy and adverse reactions of the two groups were compared. Results The clinical efficacy of the observation group was better than that of the control group, and the incidence of adverse reactions was lower than that of the control group (P <0.05). Conclusion The clinical efficacy of omeprazole in the treatment of gastroesophageal reflux disease is better than that of ranitidine, which can effectively improve the clinical symptoms and signs of patients and has good safety.