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伤寒的诊断一直是根据血培养及Widal试验,但有27.6%的病例不能依赖Widal试验;虽然血培养适合于早期诊断,但最少需要2天,而且当血液标本中细菌极少时可出现假阴性.我们根据Sivadason等的伤寒患者尿中伤寒杆菌抗原持续存在的原理,用高效价的抗伤寒杆菌抗体标记金黄色葡萄球菌A蛋白的协同凝集试验(SPA—COA)试验.检测50例伤寒患者尿中伤寒杆菌抗原,并设非伤寒发热患者15例作为对照观察,现将结果报告如下; 材料和方法一、检测对象:1986年7～9月住院病人中确诊为伤寒的50例患者为观察组(A),同期非伤寒发热患者15例为对照组(B).A组男36例,女14例,年龄3～62岁,经血培养证实伤寒者27例,骨髓培养证实者18例,大便培养证实者19例,尿培养证实者5例,三项培养阳性者3例,二项培养阳性5例.B组男11例,女4例,年龄31/2～54岁,其中急性菌痢5例,血液病及肺部
The diagnosis of typhoid fever has been based on blood cultures and Widal tests, but 27.6% of cases can not rely on the Widal test; while blood culture is suitable for early diagnosis, it takes at least 2 days and false negatives occur when there are few bacteria in the blood specimen According to the persistence of urinary Salmonella typhi antigen in patients with typhoid fever such as Sivadason, SPA-COA test of Staphylococcus aureus protein A with high titer anti-Salmonella typhimurium antibody was performed. In the typhoid fever bacillus antigen and non-typhoid fever in 15 patients as a control observation, the results are reported as follows; Materials and methods First, the test object: July to September 1986 inpatients diagnosed as typhoid fever in 50 patients were observed (A), 15 cases of non-typhoid fever in the same period as the control group (B) .A group of 36 males and 14 females, aged 3 to 62 years, blood culture confirmed typhoid fever in 27 cases, bone marrow culture confirmed in 18 cases, There were 19 confirmed cases in urine culture, 5 confirmed urine cultures, 3 positive in 3 cultures and 5 positive in 2 cultures.B group 11 males and 4 females, aged 31 to 54 years, with acute bacillary dysentery 5 cases, blood diseases and lungs