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目的 探讨细胞周期素 D1 (cyclin D1 )在乳腺癌中与雌激素受体 (ER)、孕激素受体 (PR)之间的关系。 方法 应用免疫组化 SP法 ,对 6 6例原发性乳腺癌进行 cyclin D1 及 ER、PR表达的检测。 结果 cyclin D1 的表达在 ER阳性者中阳性率为 84.8% (2 8/ 33) ,在 ER阴性患者中的阳性表达率为 5 4.5 % (18/ 33) ,二者差异有显著性 (P<0 .0 1)。 结论 雌激素对乳腺癌的发生作用可能通过 cyclin D1 途径 ,对 cyclin D1 、ER的检测可能为乳腺癌的临床治疗提供有益的参考。
Objective To investigate the relationship between cyclin D1 and estrogen receptor (ER) and progesterone receptor (PR) in breast cancer. Methods Immunohistochemical SP method was used to detect the expression of cyclin D1, ER and PR in 66 cases of primary breast cancer. Results The positive rate of cyclin D1 expression was 84.8% (28/33) in ER positive patients and 5.5% (18/33) in ER negative patients, the difference was significant (P < 0 .0 1). Conclusion The effect of estrogen on breast cancer may be through the cyclin D1 pathway. The detection of cyclin D1 and ER may provide useful reference for the clinical treatment of breast cancer.