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1988年3月,作者在西班牙某医院的高危医务人员中进行非盲随机对照试验。对69名健康人员(女36名,男33名)年龄为20～40岁,血清转氨酶水平正常,体重(相对身高)不超过标准的10%,进行初免。根据年龄分成两个男女配对组(年龄允许相差1岁),在0、1、6个月进行肌肉(20μg/剂)或皮内注射(2μg/剂)3剂同一批号的重组乙型肝炎疫苗。1988年12月,有51名职员(女22名,男29名)的抗体滴度<160IU/L,用同一批号疫
In March 1988, the authors conducted a non-blinded randomized controlled trial of high-risk medical staff at a Spanish hospital. Sixty-nine healthy individuals (36 males and 33 males) were 20 to 40 years of age with normal serum aminotransferase levels and no more than 10% of their body weight (relative height), as the initial exemption. Divided into two males and females according to age (1 year of age allowed to differ). Muscle (20 μg / dose) or intradermal injection (2 μg / dose) of 3 doses of the same batch of recombinant hepatitis B vaccine . December 1988, 51 staff (female 22, male 29) antibody titer <160IU / L, with the same batch of epidemic