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[Objective]To study the effect of the Chinese traditional medicine arbutin on brain cells after ischemia-reperfusion injury and provide a theoretical foundation for its clinical application. [Methods]Forty Kunming mice were randomly divided into four groups,namely the blank group,the ischemia-reperfusion group,the chemoprophylaxis group and the medication group. The cerebral ischemia-reprefusion model,made according to the principle of brain damage caused by ischemia,was stained with TTC and HE to observe cells’ morphological changes.SOD activity,MDA content and GSH-Px activity in brain tissues were tested. [Results]Compared with the ischemia-reperfusion group,necrosis of ischemia areas stained by TTC in the chemoprophylaxis group and the medication group was less obvious. HE staining showed the alleviation of cells damage. The enhancement of SOD activity and that of GSH-Px activity showed significant differences. MDA content was reduced(P <0.05 for both). [Conclusions]Arbutin had antioxidant properties which can effectively prevent and protect brain cells from damage.
[Objective] To study the effect of the Chinese traditional medicine arbutin on brain cells after ischemia-reperfusion injury and provide a theoretical foundation for its clinical application. [Methods] Forty Kunming mice were randomly divided into four groups, namely the blank group, the ischemia-reperfusion group, the chemoprophylaxis group and the medical group. The cerebral ischemia-reprefusion model, made according to the principle of brain damage caused by ischemia, was stained with TTC and HE to observe cells’ morphological changes. SOD activity, MDA content and GSH-Px activity in brain tissues were tested. [Results] Compared with the ischemia-reperfusion group, necrosis of ischemia areas stained by TTC in the chemoprophylaxis group and the medication group was less obvious. HE staining showed the alleviation of cells damage. The enhancement of SOD activity and that of GSH-Px activity showed significant differences. MDA content was reduced (P <0.05 for both). [Conclusions] Arbutin had anti oxidant properties which can effectively prevent and protect brain cells from damage.