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目的:探讨降钙素原(PCT)在脓毒血症早期诊断及预后评估中的意义。方法:选取2013-06-2015-06皖南医学院第一附属医院收治的脓毒血症患者共50例为观察组,另选取非脓毒血症患者共50例为对照组。所有脓毒血症患者分别于抗菌药物治疗前、抗菌药物治疗后1d、5d、9d测定血清PCT水平,同时检测对照组血清PCT水平。结果:(1)观察组在使用抗菌药物治疗之前,血清PCT水平明显高于对照组水平(t=20.01,P<0.01);(2)严重脓毒血症组和脓毒血症伴休克组血清PCT水平高于脓毒血症组,脓毒血症伴休克组血清PCT水平高于严重脓毒血症组;(3)在使用抗菌药物治疗之后,预后良好组血清PCT水平迅速下降(P<0.01);而预后不良组血清PCT浓度始终维持在较高水平。结论:PCT可作为脓毒血症的早期诊断指标,并可用于反映患者的病情严重程度以及对疾病的预后进行评估。
Objective: To investigate the significance of procalcitonin (PCT) in the early diagnosis and prognosis evaluation of sepsis. METHODS: Fifty patients with sepsis admitted to the First Affiliated Hospital of Wannan Medical College from 2013-06-2015-06 were selected as the observation group. Fifty patients with non-sepsis were selected as the control group. All patients with sepsis before treatment with antimicrobial agents, anti-bacterial drug treatment after 1d, 5d, 9d serum PCT levels, while the control group serum PCT levels. Results: (1) Before treatment with antibiotics, the level of serum PCT in the observation group was significantly higher than that in the control group (t = 20.01, P <0.01); (2) In severe sepsis group and sepsis with shock group Serum PCT levels were higher in the sepsis group than those in the sepsis group and sepsis with shock group. (3) After treatment with antibiotics, the serum PCT level dropped rapidly in the good prognosis group (P <0.01). However, the serum PCT concentration in the poor prognosis group was always maintained at a high level. Conclusions: PCT can be used as an early diagnostic indicator of sepsis and can be used to reflect the severity of the patient’s condition and assess the prognosis of the disease.