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目的探讨四川省安岳县艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(HIV/AIDS病人)抗病毒治疗的效果及相关状况,为艾滋病的综合防治提供基础资料和科学依据。方法采用前瞻性随访研究方法,对HIV/AIDS病人的实验室检查相关结果、治疗方案及随访情况做描述性分析、重复测量方差分析、Logistic回归分析。结果 42例病人治疗前、治疗半年后及治疗1年后,CD+4T淋巴细胞(简称CD4细胞)计数的变化差异有统计学意义(F=307.93,P<0.001);当基线CD4细胞计数<200个/μL时,其出现治疗效果较差的危险性是基线CD4细胞计数≥200个/μL的5.675倍;基线CD4细胞计数<200个/μL,发生艾滋病相关死亡的风险较大。按医嘱定期检查肝功、血常规等的次数,随着治疗时间的延长而逐渐减少。结论抗病毒治疗后,病人身体素质有所提高;基线CD4细胞计数越低,治疗效果就越差;抗病毒治疗病人随着治疗时间的增加,依从性逐渐降低。
Objective To investigate the effect and related status of antiviral therapy for HIV / AIDS patients (HIV / AIDS patients) in Anyue County, Sichuan Province, and to provide basic information and scientific basis for the comprehensive prevention and treatment of AIDS. Methods A prospective follow-up study was conducted. The results of laboratory tests, treatment regimens and follow-up of HIV / AIDS patients were analyzed by descriptive analysis and repeated measures ANOVA and Logistic regression analysis. Results There were significant differences in the counts of CD + 4T lymphocytes (F = 307.93, P <0.001) before treatment, half a year and one year after treatment in 42 patients. When the baseline CD4 count < At 200 / μL there is a 5.675-fold risk of poor response to treatment with baseline CD4 counts ≥200 / μL; baseline CD4 counts <200 / μL, and a greater risk of AIDS-related death. According to doctor’s advice regularly check the number of liver function, blood routine and so on, with the extension of treatment time and gradually reduced. Conclusions The patient’s physical quality has been improved after antiviral treatment. The lower the baseline CD4 cell count, the worse the treatment effect. The anti-virus treatment patient’s compliance gradually decreases with the increase of treatment time.