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应用传统的同位素标记方法诊断蛋白丧失性肠病(PLE)较复杂,尤其对小儿有很多缺点,包括粪标本易被尿污染,进行试验必须住院,而且~(51)Cr标志的白蛋白供应也有限。A_1-抗胰蛋白酶(A-1-AT)系-抗酶(An-tienzyme)对蛋白分解酶具抗力;如排泄入肠道,则将以不变的形式随粪便排出。A-1-AT约占血清蛋白质总量的4％,分子量为50,000dalton,与白蛋白相仿。所以粪便中,A-1-AT(FA-1-AT)的排泄应与白蛋白丧
It is more complicated to diagnose protein-losing enteropathy (PLE) by traditional isotope labeling method. In particular, there are many shortcomings in children, including the stool specimen being easily contaminated by urine, hospitalization for testing, and the supply of albumin (51) Cr limited. A 1-Antitrypsin (A-1-AT) -Anti-tienzyme is resistant to proteolytic enzymes; excretion into the intestine will then be excreted with the feces in a constant form. The A-1-AT accounts for about 4% of the total serum protein and has a molecular weight of 50,000 daltons, similar to albumin. Therefore, excretion of A-1-AT (FA-1-AT) in feces should be related to albumin furans