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洛美沙星为一新型氟喹诺酮类药物,其抗菌谱广,抗菌作用强,本文报道其体内外抗菌作用的研究结果。洛美沙星对革兰氏阴性菌具强大的抗菌作用,其MIC_(90)大都≤2mg/L,对大肠杆菌、流感杆菌和淋球菌的抗菌作用尤强,对肺炎球菌和其他链球菌的抗菌作用较弱。对大部分耐庆大霉素和哌拉西林的革兰氏阳性杆菌仍具良好抗菌活性。洛美沙星的抗菌作用略逊于环丙沙星,与氧氟沙星相似,稍优于诺氟沙星。洛美沙星对小鼠实验性细菌感染,尤其是革兰氏阳性杆菌感染具有明显保护作用,其口服用药后的体内抗菌作用明显优于诺氟沙星。
Lomefloxacin is a new type of fluoroquinolones, its broad antibacterial spectrum, strong antibacterial activity, this article reports its antibacterial effect in vivo and in vitro studies. Lomefloxacin against Gram-negative bacteria with a strong antibacterial effect, the MIC_ (90) mostly ≤ 2mg / L, against Escherichia coli, influenza and gonorrhea has particularly strong antibacterial effect on pneumococcus and other Streptococcus antibacterial Weak. Gram positive bacteria resistant to gentamicin and piperacillin are still good antibacterial activity. Lomefloxacin antibacterial effect slightly inferior to ciprofloxacin, and ofloxacin similar to slightly better than norfloxacin. Lomefloxacin on mice experimental bacterial infections, especially Gram-positive bacilli infection has a significant protective effect of oral antibacterial effect was significantly better than norfloxacin.