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目的探讨母婴血型不合导致的新生儿溶血病实验室指标分析。方法选取2009年1月至2012年12月210对夫妻及新生儿,对其血型进行鉴定,采集新生儿血液进行直接抗人球蛋白试验、抗体释放试验、游离抗体试验;并将产后母血做IgG抗A(B)抗体效价予以试验分析,观察其指标对比。结果通过检测,新生儿溶血病发病率22.9%(48/210)。O-A-A型阳性率33.3%,O-B-B型阳性率13.3%,O-AB-A型阳性率28.6%,O-AB-B型阳性率20.0%,母血清效价超过1∶32者有71.4%。结论新生儿溶血疾病具有较高发病率,对其临床征兆需及早发现并诊断,及时进行治疗。
Objective To investigate the laboratory analysis of neonatal hemolytic disease caused by incompatible maternal and child blood group. Methods A total of 210 couples and newborns from January 2009 to December 2012 were enrolled in this study. Their blood type was identified. Neonatal blood was collected for direct anti-human globulin test, antibody release test and free antibody test. Postpartum maternal blood IgG anti-A (B) antibody titers to be tested and analyzed to observe the indicators comparison. Results through testing, the incidence of neonatal hemolytic disease was 22.9% (48/210). The positive rate of O-A-A type was 33.3%, the positive rate of O-B-B type was 13.3%, the positive rate of O-AB-A type was 28.6%, the positive rate of O-AB-B type was 20.0%. Conclusion Newborn hemolytic disease has a high incidence, clinical signs of early detection and diagnosis, timely treatment.