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探讨舌鳞癌中CD44v6蛋白的表达及其对舌鳞癌进展和转移的影响。应用常规ABC免疫组织化学染色技术检测 40例舌鳞癌组织中CD44v6的表达 ,其中包括无淋巴结转移 2 4例及有淋巴结转移 16例 ,舌乳头状瘤 12例及正常舌粘膜组织 9例。结果显示 ,舌鳞癌组织中CD44v6阳性率为 72 5 % (2 9/ 40 ) ,有淋巴结转移者CD44v6高表达的阳性率为 81 3 % (13/ 16 ) ,无淋巴结转移者CD44v6高表达的阳性率为 41 7% (10 / 2 4) ;舌乳头状瘤中仅有 2例阳性高表达 ,阳性率为 16 7% (2 / 12 ) ;而正常舌粘膜组织中未见有CD44v6蛋白的表达。研究表明 ,对舌鳞癌组织进行CD44v6蛋白的检测 ,有助于预测其进展程度和对淋巴结转移的诊断
To investigate the expression of CD44v6 in tongue squamous cell carcinoma and its influence on the progression and metastasis of tongue squamous cell carcinoma. The expression of CD44v6 in 40 cases of tongue squamous cell carcinoma was detected by routine ABC immunohistochemical staining, including 24 cases without lymph node metastasis, 16 cases with lymph node metastasis, 12 cases with tongue papilloma and 9 cases with normal tongue mucosa. The positive rate of CD44v6 in tongue squamous cell carcinoma was 72.5% (29/40). The positive rate of CD44v6 in lymph node metastasis was 81.3% (13/16). The positive rate of CD44v6 in tongue squamous cell carcinoma The positive rate was 41.7% (10/2 4). Only 2 cases of tongue papilloma were positive and the positive rate was 16.7% (2/12), while there was no CD44v6 protein in normal tongue mucosa expression. Studies have shown that the detection of CD44v6 protein in tongue squamous cell carcinoma is helpful to predict its progression and diagnosis of lymph node metastasis